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Stud Mycol 61(1): 61-66 2008
DOI: 10.3114/sim.2008.61.05
Copyright © 2008 CBS Fungal Biodiversity Centre
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HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi

T. Vaupotic1, P. Veranic2, U. Petrovic3, N. Gunde-Cimerman4 and A. Plemenitas1,*

1 Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov Trg 2, 1000 Ljubljana, Slovenia.
2 Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Vrazov Trg 2, 1000 Ljubljana, Slovenia.
3 Department of Biochemistry and Molecular Biology, Institute Jozef Stefan, Jamova 39, 1000 Ljubljana, Slovenia.
4 Biology Department, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia

* Correspondence: Ana Plemenitas, ana.plemenitas{at}mf.uni-lj.si

The activity and level of HMG-CoA reductase (HMGR) were addressed in halophilic fungi isolated from solar saltpans. Representative fungi belonging to the orders Dothideales, Eurotiales and Wallemiales have a specific pattern of HMGR regulation, which differs from salt-sensitive and moderately salt-tolerant yeasts. In all of the halophilic fungi studied, HMGR amounts and activities were the lowest at optimal growth salinity and increased under hyposaline and hypersaline conditions. This profile paralleled isoprenylation of cellular proteins in H. werneckii. Inhibition of HMGR in vivo by lovastatin impaired the halotolerant character. HMGR may thus serve as an important molecular marker of halotolerance.

Keywords Adaptation / extremophiles / isoprenylation / lovastatin / mevalonate regulation






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